Fermented Oyster Extract(FGO), a raw material for children's height growth

 1. Product Name: Fermented Oyster Extract (FGO) (K-FDA: No. 2024-26)

• Ingredients: Oysters (Crassostrea gigas)
• Appearance: A yellowish-brown, particle-free powder with a unique flavor and no off-flavor or odor.

2. Index Ingredients

• GABA (γ-aminobutyric acid): 115 mg/g (80–120% of labeled amount)
• Taurine: 3.4 mg/g (80–120% of labeled amount)

3. Production Process

• Fermentation process: Fresh oysters are fermented for 48 hours at 37℃ using the patented strain Lactobacillus brevis BJ20.
• Premium ingredient: Through advanced refining, concentration, and powdering, the result is a high-quality material with significantly enhanced functional components compared to conventional raw oysters.

4. Significance (Regarding Stability)

• Excellent pH stability
• High-temperature stability
• 100% water-soluble, suitable for various formulations such as beverages, powders, and capsules

5. In-vivo

• Change in bone formation and growth hormone : FGO intake promotes bone formation/regeneration and length growth through increased expression of growth-related genes.

• Change in Bone formation index: FGO intake promotes bone formation via activation of the Wnt/β-catenin pathway.

Bone formation & density growth in an ovariectomized model: FGO intake improves bone density in the ovariectomy model.

6. Clinical Trials 

- Height Growth in Children-

• Effect of FGO on Pediatric Height Growth and Safety Comparison
• Randomized, double-blind, controlled  human clinical trial for evaluation research.
• 24-week intake, randomized, double-blind, parallel-design, placebo-controlled study.

Phase I Human Clinical Trial

Phase II Human Clinical Trial

- Bone Health -

• Effects of FGO intake on bone health and safety evaluation.
• Multicenter, randomized, double-blind, controlled human clinical trial.
• 24-week intake, randomized, double-blind, parallel-design, placebo-controlled study.